PCSK9 deficiency: A double-edged sword?
نویسندگان
چکیده
منابع مشابه
PCSK9 and carbohydrate metabolism: A double-edged sword
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic d...
متن کاملA Double-Edged Sword?
The enormous benefits of inhibition of ACE demonstrate that manipulation of the metabolism of peptide hormones is a valuable therapeutic strategy for cardiovascular disease. Recent attempts to expand these benefits have combined ACE inhibition with inhibition of other peptidases such as neutral endopeptidase (NEP) in a single molecule, a strategy known as vasopeptidase inhibition. NEP metaboliz...
متن کاملA Double-Edged Sword
Ischemic heart disease remains a leading cause of morbidity and mortality. The survival after acute ischemic events has improved substantially in recent years, but new syndromes have emerged. Cardiac remodeling following a large myocardial infarction, with dilatation of the left ventricle, has deleterious hemodynamic consequences and is a major cause of chronic heart failure.1 The increased inc...
متن کاملMitochondrial deficiency: a double-edged sword for aging and neurodegeneration
For decades, aging was considered the inevitable result of the accumulation of damaged macromolecules due to environmental factors and intrinsic processes. Our current knowledge clearly supports that aging is a complex biological process influenced by multiple evolutionary conserved molecular pathways. With the advanced age, loss of cellular homeostasis severely affects the structure and functi...
متن کاملHerbicides — A Double Edged Sword
Weeds represent a global agronomic problem that threatens the productivity of cultivated crops. Weeds compete with cultivated crops for the available moisture, nutrients and light. Consequently, weeds significantly reduce either crop yield or quality. Control of weeds is essential to maintaining the production of economic crops. Weed control may be achieved either through manual eradication or ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Preventive Cardiology
سال: 2017
ISSN: 2047-4873,2047-4881
DOI: 10.1177/2047487317733565